New Orleans Saints standout running back Alvin Kamara was ruled out of Thursday night's game against the Buffalo Bills due to his knee injury.
It marks the third straight game the 26-year-old Kamara will miss. He didn't practice this week.
Kamara was initially hurt during a loss to the Atlanta Falcons on Nov. 7. He has 530 yards and three touchdowns on the ground and has 32 receptions for 310 yards and four scores through the air in eight games.
Mark Ingram II, the probable starter, was limited in Wednesday's practice due to a knee injury. The Saints listed him as questionable to play against the Bills.
Ingram rushed for a season-best 88 yards on 16 carries in last week's 40-29 loss to the Philadelphia Eagles. He has 205 yards and one touchdown on 45 carries and caught 17 passes for 132 yards in four games since joining the Saints.
New Orleans also ruled out offensive tackle Ryan Ramczyk (knee) and defensive ends Marcus Davenport (shoulder) and Tanoh Kpassagnon (ankle).
Offensive tackle Terron Armstead (knee, shoulder) is questionable.
--Field Level Media